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Delivery conjugates

Peptide, PPMO and lipid oligonucleotide conjugates

Oligos linked to cell-penetrating peptides (CPP), peptide-PMO (PPMO) constructs, cholesterol and other lipid anchors, and miscellaneous delivery ligands. Conjugation chemistry preserves oligo integrity while enabling uptake in muscle, CNS and other tissues beyond GalNAc-liver programs.

All oligonucleotides

CPP

peptide conjugates

PPMO

peptide + morpholino

Chol

lipid anchor

SMCC / NHS

linker chemistries

HIC

conjugate purity tool

POC, PPMO and lipid conjugates

Peptide-oligonucleotide conjugates (POC) attach arginine-rich or amphipathic CPPs to improve cellular uptake of charged phosphorothioate or duplex payloads in culture and in vivo models.

PPMO combines a morpholino oligomer with a cell-penetrating peptide for steric splice modulation in tissues where naked PMO uptake is limited. Lipid conjugates such as cholesterol or tocopherol anchors associate conjugates with lipoprotein transport and can enhance extrahepatic distribution patterns in exploratory programs.

Conjugate class selection

NeedFormatIndicative linkage
Culture / muscle uptake of ASOCPP-ASO3' or 5' peptide via amide / thioether
Exon skip with PMOPPMOPeptide N-terminus to PMO 3' or custom scaffold
Broad tissue distributionCholesterol-oligo3' cholesterol via post-synthetic conjugation
Liver (systemic SC)GalNAcSee GalNAc Conjugates page

Figures are indicative industry-typical values. Lot- and project-specific data appear on the quotation and certificate of analysis.

Peptide and lipid catalog (examples)

CPP motifs (examples)

  • Tat-derived sequences
  • Transportan / Penetratin class
  • Custom CPP sequence you provide
  • PNA-peptide hybrids (project-specific)

Lipids

  • Cholesterol
  • α-tocopherol
  • Fatty acids (C16, C18)
  • DSPE-PEG-mal (for nanoparticle coupling studies)

PPMO

  • Morpholino + polyarginine or proprietary CPP
  • Site-specific vs stochastic peptide loading (quoted separately)

Indicative conjugate QC

Identity

LC-MS

Peptide + oligo mass

Conjugation efficiency

Reported

Free oligo / peptide residuals

Purity

HIC / RP-HPLC

Hydrophobic conjugates

Peptide integrity

MS / peptide mapping

When peptide is large

PMO integrity

Morpholino MS

Unchanged PMO length

Figures are indicative industry-typical values. Lot- and project-specific data appear on the quotation and certificate of analysis.

What you receive

  • Purified conjugate with COA
  • MS of intact conjugate
  • Residual starting material report
  • Recommended solvent (often aqueous with organic co-solvent for lipids)
  • Stability guidance for peptide-bearing conjugates
  • Quote with peptide sequence length and conjugation chemistry

Frequently asked questions

Peptide-oligo conjugates can use supplied peptide or peptide synthesized under the same project scope; quote clarifies split.

Related

GalNAc Conjugates

N-acetylgalactosamine (GalNAc) ligands conjugated to siRNA, ASO or antisense payloads route uptake via asialoglycoprotein receptor (ASGPR) on hepatocytes. Tri-antennary GalNAc clusters are the dominant motif for systemic subcutaneous dosing in modern RNAi programs.

View details

miRNA, PMO & Aptamers

Oligonucleotides beyond classic ASO/siRNA: double-stranded miRNA mimics, single-stranded anti-miRs, phosphorodiamidate morpholino oligomers (PMO), and DNA or 2'-modified aptamers for target binding. Each class uses a distinct backbone and analytics approach.

View details

Antisense (ASO)

Single-stranded phosphorothioate-rich ASOs for RNase H–mediated knockdown (gapmers) or sequence-specific binding without degradation (steric blockers). Chemistry, length and modification pattern are chosen to the target transcript, tissue and intended clinical dose.

View details

Clinical & Commercial GMP

GMP manufacturing of oligonucleotide drug substance for clinical trials and commercial supply: batch records, validated release and stability methods, change control, and documentation packages suitable for regulatory filing — described at capability level without inventing facility certifications.

View details
Next step

Ready to specify this for your program?

Share sequence, scale and documentation needs. We reply with indicative specs and a project-specific quotation.