Cosmetic peptides for topical and rinse-off formulations
Signal peptides, carrier peptides and synthetic neuropeptide mimics for skin and hair care, supplied at cosmetic raw material purity with INCI-aligned naming and documentation suitable for PIF and safety assessments—not pharmaceutical release unless separately contracted.
>95%
typical purity band
INCI
naming on COA
g–kg
raw material lots
Cosmetic
grade intent
Water
content reported (typical)
Cosmetic grade framing
Cosmetic peptides are supplied as ingredients for formulation, not as drug products. Purity targets are often >95% with clarity on counter-ion and microbial quality appropriate for topical use.
INCI names on documentation align with industry dictionaries (e.g. sh- or synthetic peptide designations where applicable). Regulatory responsibility for finished cosmetic compliance remains with the brand owner.
Common cosmetic peptide classes
Signal / matrikine mimics
- Palmitoyl tripeptide-1 / -5 variants (collagen messaging)
- Palmitoyl tetrapeptide-7 (comfort / redness positioning)
- Hexapeptide-9, nonapeptide-1 (brightening claims support)
Carrier peptides
- Copper tripeptide-1 (GHK-Cu)
- Biotinoyl tripeptide-1 for hair aesthetics
Expression / neuromodulator mimics
- Acetyl hexapeptide-3/8 (topical ‘expression’ peptides)
- Pentapeptide-18 (snap-25 motif analogs)
Custom cosmetic sequences
- Lipidated short peptides for penetration
- PEG-free, preservative-compatible salt forms
Typical cosmetic raw material specification
INCI designation
Stated on COA and SDS
Brand maps to finished product label
Purity (HPLC)
>95% common
>98% available for premium positioning
Identity
MS
Required for novel sequences
Heavy metals
Per cosmetic raw material limit (indicative)
Confirm with safety assessor
Microbial quality
TAMC / TYMC limits
Aligned to ISO 17516-style bands
Peptide content
On request
Important for lipidated peptides
Appearance
White to off-white powder
Liquid pre-dissolved on request
Figures are indicative industry-typical values. Lot- and project-specific data appear on the quotation and certificate of analysis.
Formulation considerations
| Factor | Guidance | Documentation |
|---|---|---|
| Lipophilic tail | Palmitoyl / myristoyl for epidermal delivery | Confirm lipid content on COA |
| pH stability | Avoid prolonged high pH for ester-linked lipids | Stress data on request |
| Preservative interaction | Formaldehyde donors may affect Trp/Met sequences | Formulator stability panel |
| Solubility | Acetate salts often preferred over TFA for marketing story | Salt form on spec |
| Vegan / animal origin | Synthetic SPPS, no animal enzymes | Statement letter typical |
Figures are indicative industry-typical values. Lot- and project-specific data appear on the quotation and certificate of analysis.
Supply workflow
Select catalog or custom INCI peptide
Purity, salt and pack size matched to annual formulation volume.
Regulatory paperwork
SDS, INCI, composition disclosure for PIF; allergen declaration if applicable.
QC release
HPLC, MS and microbial panel per cosmetic spec.
Shipment
Ambient or cold per stability data; lot traceability for recall readiness.
Frequently asked questions
Supply is quoted to the sequence and salt that underpin the INCI. Changing lipid length or sequence may require a new INCI consultation.
Related
Custom Peptide Synthesis
Solid-phase and solution synthesis of linear and modified peptides for discovery, assay development and lead optimization. Scale, purity tier and QC depth are matched to how the material will be used—not every program needs the same finishing step.
View detailsPeptide Modifications
Terminal caps, cyclization, stapling, PTMs, fluorescent and affinity tags, PEG/lipid appendages and unnatural backbones—installed during SPPS or in solution after the chain is built. Each class changes synthesis time, purification and how the product should be specified on the COA.
View detailsAmino Acid Derivatives
Fmoc and Boc protected amino acids, pseudoproline dipeptides, phosphorylated and unnatural derivatives, and pre-activated forms for SPPS. Lot-enantiomeric purity at the monomer propagates into the final peptide—especially on long sequences.
View detailsDiagnostic & Device Peptides
Highly controlled peptides for immunoassays, biosensors, calibration curves and device coatings—where lot-to-lot consistency, label integrity and low host-interference matter more than gram-scale bulk.
View detailsReady to specify this for your program?
Share sequence, scale and documentation needs. We reply with indicative specs and a project-specific quotation.