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Pre-loaded

Pre-loaded Fmoc-amino acid Rink Amide AM

C-terminal Fmoc-amino acid loaded on Rink Amide AM support. Start amide-oriented SPPS with qualified loading and avoid first-coupling variability when delivering CONH2 peptides.

All resins

Rink AM

amide support

Fmoc-AA

attached

0.3–0.7

mmol/g typical

CONH2

final terminus

COA

loading

Ready for amide synthesis

The first esterification on Rink Amide sets the stereochemistry and effective loading for the entire synthesis. Pre-loaded AM resin is coupled under supplier QC so your first operation is Fmoc removal and installation of residue 2.

Use when programs share a common C-terminal amino acid and require C-terminal carboxamide release after TFA cleavage.

Typical specifications

Support

Rink Amide AM

Not MBHA on standard pre-load SKU

Product terminus

Carboxamide after cleavage

Plan sequence accordingly

Loading

0.3–0.7 mmol/g

COA assay

First residue

Fmoc-L-amino acid typical

Custom on quote

Cleavage

TFA scavenger

Same as base Rink AM

Figures are indicative industry-typical values. Lot- and project-specific data appear on the quotation and certificate of analysis.

Pre-loaded AM vs unattended MBHA

NeedChoose
Standard amide peptidesPre-loaded Rink Amide AM
Long peptide, aggregation on AMUnload MBHA Rink + manual load or custom quote
N-alkyl C-terminal amideIndole resin route, not Rink
C-terminal acidPre-loaded Wang or 2-CTC

Figures are indicative industry-typical values. Lot- and project-specific data appear on the quotation and certificate of analysis.

Indicative synthesis start

  1. 01

    Swell resin in DMF; piperidine Fmoc deprotection of pre-loaded residue.

  2. 02

    Couple second residue with activation method suited to sequence (HATU for hindered).

  3. 03

    Continue Fmoc SPPS; cleave with standard Rink amide TFA cocktail.

  4. 04

    Verify amide product mass by LC-MS.

Workflow

01

Order matched C-terminal AA

Align pre-loaded identity with medicinal chemistry design.

02

Use COA loading

Calculate stoichiometry from assayed mmol/g, not catalog nominal.

03

Scale with AM limits

If length exceeds AM comfort, plan MBHA for later lots.

04

Cleave to amide

No post-cleavage amidation step required when Rink is correct support.

What you receive

  • Pre-loaded Fmoc-AA-Rink Amide AM
  • COA: loading, mesh, amino acid identity
  • Cleavage guidance summary
  • Link to Rink Amide AM / MBHA selection page
  • Pack sizes for parallel library synthesis

Frequently asked questions

Standard catalog pre-load SKU is Rink Amide AM. MBHA pre-load is quoted custom.

Related

Rink Amide AM / MBHA

para-(Rink amide) benzyl ester supports deliver peptides with C-terminal CONH2 after TFA cleavage. Choose AM (aminomethyl) for standard lengths or MBHA (4-methylbenzhydrylamine) when higher swelling and softer aggregation help long or difficult sequences.

View details

Pre-loaded Wang

Fmoc-amino acids esterified on Wang with lot-documented loading. Skips the racemization-prone first coupling and accelerates campaigns where the C-terminal residue is His, Cys, or otherwise sensitive to manual loading.

View details

Ethyl & Methyl Indole Resins

Indole-derived linkers on polystyrene enable C-terminal N-ethyl and N-methyl carboxamides after TFA cleavage—motifs common in GnRH analogs such as leuprolide. Chemistry differs from Rink: first coupling to the linker is inefficient under carbodiimide alone; HATU (or similar uronium) is required.

View details
Next step

Ready to specify this for your program?

Share sequence, scale and documentation needs. We reply with indicative specs and a project-specific quotation.