Continuous flow chemistry
Hazardous, fast, or highly exothermic transformations run in continuous reactors where residence time, temperature, and pressure are controlled more tightly than in classical batch—improving safety margins and often throughput for key steps.
Bar
pressure-capable skids
Cryo
low-temp flow loops
Mixing
static & micromixer
Hybrid
flow + batch API
When flow wins
Flow chemistry excels when the hazard scenario is holding a large inventory of reactive species—diazo intermediates, azides, nitrating mixtures, or metallated reagents at cryogenic temperature. Smaller instantaneous volumes and precise residence time reduce runaway potential.
Not every step belongs in flow. Workups, crystallizations, and polymorph control often remain batch. We design hybrid routes rather than forcing continuous operation where it adds complexity without safety or cost benefit.
Batch vs flow decision guide
| Reaction profile | Batch risk | Flow consideration |
|---|---|---|
| Highly exothermic addition | Heat removal lag | Microreactor or coil with inline quench |
| Short-lived intermediate (<30 s) | Decomposition in vessel | Precise residence time tubing |
| Pressurized gas dissolution | Headspace variability | Continuous gas-liquid contactors |
| Gentle aqueous crystallization | Mature batch design | Often remain batch |
Figures are indicative industry-typical values. Lot- and project-specific data appear on the quotation and certificate of analysis.
Flow development workflow
Lab coil or chip mapping
Establish kinetics, selectivity, and impurity profile versus batch baseline.
Scale-out
Increase reactor volume and flow rates while holding residence time; confirm mixing Re regimes.
Inline analytics
Optional IR or UPLC checkpoints for steady-state detection before collection.
Integration with downstream
Quench, extraction, or crystallization receiving stream from flow output.
Indicative flow capabilities
Temperature range
−78 °C to 200+ °C
Module dependent
Pressure
Up to ~50 bar
Higher on custom skids
Solvent scope
Common organic/aqueous
HF not in scope
Output
g/h to kg/day
Campaign-based collection
Figures are indicative industry-typical values. Lot- and project-specific data appear on the quotation and certificate of analysis.
Frequently asked questions
No. We provide contracted development and manufacturing services using in-house skids.
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View detailsReady to specify this for your program?
Share sequence, scale and documentation needs. We reply with indicative specs and a project-specific quotation.