Skip to content

For research and pharmaceutical organizations only. No consumer sales.

Solenyx Logo
Pre-loaded

Pre-loaded Fmoc-amino acid 2-CTC resin

Fmoc-amino acids on 2-chlorotrityl resin with verified loading. Ideal starting point for protected fragments, C-terminal Pro/Gly sequences, and projects that combine mild cleavage with skip-the-first-load convenience.

All resins

Fmoc-AA-CTC

ready to elongate

0.4–0.8

mmol/g typical

Mild

cleavage option

Fragment

export ready

COA

per lot

Pre-loaded 2-CTC

Manual loading onto 2-CTC requires care with base and coupling agent to avoid over-acylation and epimerization. Pre-loaded material transfers that risk to the supplier process and gives a traceable starting point for fragment synthesis.

Teams running convergent synthesis often standardize on one pre-loaded C-terminal residue per scaffold, then mild-cleave identical handles across a series.

Typical specifications

Support

2-Chlorotrityl polystyrene

Mesh on COA

First residue

Fmoc-amino acid ester

Identity on label

Loading

0.4–0.8 mmol/g

Assayed per lot

Cleavage options

Mild or global

Same as base 2-CTC

Storage

Cool, dry, inert

Moisture-sensitive support

Figures are indicative industry-typical values. Lot- and project-specific data appear on the quotation and certificate of analysis.

Pre-loaded 2-CTC vs manual load

FactorManual 2-CTC loadPre-loaded 2-CTC
ReproducibilityOperator-dependentLot COA loading
Time to cycle 1Extra dayDeprotect and couple #2
Pro/Gly C-termHigh skill loadSupplier-optimized loading
Custom rare AAFlexibleQuote lead time

Figures are indicative industry-typical values. Lot- and project-specific data appear on the quotation and certificate of analysis.

Indicative fragment start

  1. 01

    Swell pre-loaded 2-CTC in DMF; Fmoc deprotection as standard.

  2. 02

    Complete SPPS; mild cleave with 1–2% TFA/DCM for protected fragment.

  3. 03

    Or global TFA cleavage for fully deprotected acid if required.

  4. 04

    LC-MS verify both fragment mass and absence of early DKP when Pro/Gly present.

Workflow

01

Match C-terminal AA to analog series

Lock one pre-loaded SKU per program for SAR consistency.

02

Elongate with Fmoc

Standard reagents; consider lower loading equivalents on difficult couplings.

03

Mild cleave for inventory

Build a protected fragment bank for ligation or hybrid steps.

04

Document lot linkage

Retain COA in batch record for regulatory or tech transfer.

What you receive

  • Pre-loaded Fmoc-AA-2-CTC with lot traceability
  • COA with loading assay and amino acid identity
  • Mild cleavage compatibility note on packet
  • Cross-link to base 2-CTC for unloaded campaigns
  • Custom AA loading quotes on request

Frequently asked questions

Yes. Use global TFA cleavage after assembly, identical to unloaded 2-CTC end games.

Related

2-Chlorotrityl (2-CTC)

Trityl chloride linker on polystyrene–DVB forms acid-labile benzyl esters. 2-CTC is the default when you need protected peptide fragments, acid-sensitive motifs, or lower diketopiperazine risk at the C-terminus than on Wang.

View details

Pre-loaded Wang

Fmoc-amino acids esterified on Wang with lot-documented loading. Skips the racemization-prone first coupling and accelerates campaigns where the C-terminal residue is His, Cys, or otherwise sensitive to manual loading.

View details

Wang Resin

p-Alkoxybenzyl alcohol linker on polystyrene–DVB. The workhorse support for Fmoc SPPS of peptides with a free C-terminal carboxylic acid, cleaved in concentrated TFA with scavengers.

View details
Next step

Ready to specify this for your program?

Share sequence, scale and documentation needs. We reply with indicative specs and a project-specific quotation.