PROTAC degraders, E3 ligands and linkers
Heterobifunctional degraders and building blocks: warheads, E3 recruiter ligands, and configurable linkers (PEG, alkyl, triazole) supplied with analytics suited to medchem and CMC teams pursuing targeted protein degradation.
VHL / CRBN
common E3 recruiters
Linker libs
length & polarity sets
Chiral
warhead support
HRMS
degrader confirmation
PROTAC design chemistry
A PROTAC links a target-binding moiety to an E3 ubiquitin ligase ligand through a linker whose length and rigidity influence ternary complex stability and cellular permeability. We supply individual components and assembled degraders, with emphasis on LC-MS-friendly purification and storage guidance for aggregates.
Linker chemistries include PEG chains, photo-labile variants for spatiotemporal control, and click-ready handles for late-stage conjugation in discovery libraries.
E3 ligase recruiter options
Selection depends on cell line E3 expression, permeability, and structural biology inputs.
CRBN (cereblon)
- Lenalidomide derivative handles
- Pomalidomide analog recruiters
- Glutarimide variants for SAR
VHL
- VH032-derived ligands
- Hydroxyproline-containing recruiters
- Short-link VHL caps for rigid tethers
Other E3 systems (on request)
- MDM2 recruiters (p53 axis programs)
- IAP / BIRC family ligands
- Novel E3 handles from literature routes
Typical degrader release (research)
Purity
≥ 95%
Prep LC or SFC available
Identity
HRMS + NMR
Linker region often key
Water
KF
PEG-rich linkers
Residual solvents
ICH Q3C
DMF, ACN common
Figures are indicative industry-typical values. Lot- and project-specific data appear on the quotation and certificate of analysis.
Conjugation approaches
Parallel library assembly
Common E3-handle plus variable linker length warhead sets for screening.
Orthogonal ligation
Amide, click, or oxime formation depending on handle placement.
Scale to lead
Chosen degrader scaled with impurity tracking on both pharmacophores.
Frequently asked questions
Yes. Bifunctional linkers with orthogonal protecting groups are a common request.
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Multi-step organic synthesis from milligram discovery batches through kilogram pilot quantities. We support heterocycles, chiral centers, organometallics and late-stage functionalization with full analytical packages at each handoff.
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Drug substance and late-stage intermediates manufactured under scalable, documented processes—bridging custom synthesis efforts to clinical and commercial demand with coherent specifications and supply continuity.
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Route scouting, reaction optimization, crystallization design, and tech transfer packages that turn a workable lab sequence into a reproducible plant-ready process—without rediscovering impurities at every scale tier.
View detailsReady to specify this for your program?
Share sequence, scale and documentation needs. We reply with indicative specs and a project-specific quotation.